International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 11  |  Issue : 2  |  Page : 80--84

Outcome of trabeculectomy with collagen matrix implant versus mitomycin C in primary glaucoma: A comparative study


Ashok K Sharma, Palak Gupta, Hans Raj Sharma 
 Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India

Correspondence Address:
Ashok K Sharma
House No. 67/1, Channi Himmat, Jammu - 180 015, Jammu and Kashmir
India

Background: Glaucoma is a serious vision-threatening condition appropriately called as the silent killer of sight. The effect of postoperative fibrosis on success of filtration surgeries requires modulation of the wound healing process. Aim: The aim of the study was to compare trabeculectomy augmented with collagen matrix implant with mitomycin C in primary glaucoma. Materials and Methods: This prospective, longitudinal, hospital-based, analytical, and interventional study was conducted on 36 eyes of 36 patients. Group 1 included 18 patients who underwent trabeculectomy combined with subconjunctival collagen matrix implant and Group 2 included 18 patients who underwent trabeculectomy augmented with intraoperative mitomycin C (0.04 mg/ml) for 2 min. Each patient underwent detailed ocular examination and comparison was drawn by recording intraocular pressure (IOP), bleb characteristics, and postoperative complications. Results: The cumulative success rates at the end of our study were similar in two groups, 94.44% in Group 1 and 88.89% in Group 2 (P = 1.000). The mean reduction in IOP at 24 weeks in Group 1 was 18.67 ± 7.59 mmHg and in Group 2 was 21.32 ± 5.84 mmHg. The reduction in IOP was similar between the two groups (P = 0.290). The mean fall in IOP was 56.46% in Group 1 and 64.70% in Group 2 at 24 weeks. Mean bleb score in Group 1 was 10.33 ± 1.23 and in Group 2 was 8.89 ± 1.41, and the difference was statistically significant (P = 0.002). Shallow anterior chamber, overfiltration, and hypotony were statistically higher in Group 2 than in Group 1 (P = 0.041, 0.041, and 0.046, respectively). Conclusion: Collagen matrix implant as an adjuvant to trabeculectomy is noble, safe, and effective option as compared to mitomycin C.


How to cite this article:
Sharma AK, Gupta P, Sharma HR. Outcome of trabeculectomy with collagen matrix implant versus mitomycin C in primary glaucoma: A comparative study.Int J App Basic Med Res 2021;11:80-84


How to cite this URL:
Sharma AK, Gupta P, Sharma HR. Outcome of trabeculectomy with collagen matrix implant versus mitomycin C in primary glaucoma: A comparative study. Int J App Basic Med Res [serial online] 2021 [cited 2021 Jun 22 ];11:80-84
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2021;volume=11;issue=2;spage=80;epage=84;aulast=Sharma;type=0