International Journal of Applied and Basic Medical Research

REVIEW ARTICLE
Year
: 2020  |  Volume : 10  |  Issue : 4  |  Page : 226--233

Lung pathology in COVID-19: A systematic review


Pinki Pandey1, Savita Agarwal1, Rajkumar2 
1 Department of Pathology, UP University of Medical Sciences, Etawah, Uttar Pradesh, India
2 Department of Neurosurgery, UP University of Medical Sciences, Etawah, Uttar Pradesh, India

Correspondence Address:
Pinki Pandey
Type V, B 101, UP University of Medical Sciences, Saifai, Etawah - 206 130, Uttar Pradesh
India

Sparse literature is available regarding autopsy findings of coronavirus disease 2019 (COVID-19) despite high mortality due to its highly contagious nature and lack of robust infrastructure for appropriate handling of the infected cases. Based on clinical findings and various diagnostic tests, it is evident that it holds the potential to affect multiple organ systems of the body preferably lungs and immune and coagulation systems. Cytokine storm-induced thrombotic complication such as disseminated intravascular coagulation is a significant feature in severe cases of COVID-19. This review captures the current information on lung histopathology in COVID-19 infection and severe respiratory failure. In COVID-19, lungs are affected bilaterally, become edematous and red/tan mottled to maroon in color with firm consistency. Distinct parenchymal changes, firm thrombi in the peripheral pulmonary vessels along with diffuse alveolar damage, have been the most consistent feature of COVID-19-related lung pathology. Electron microscopy has also been used to demonstrate viral particles.


How to cite this article:
Pandey P, Agarwal S, Rajkumar. Lung pathology in COVID-19: A systematic review.Int J App Basic Med Res 2020;10:226-233


How to cite this URL:
Pandey P, Agarwal S, Rajkumar. Lung pathology in COVID-19: A systematic review. Int J App Basic Med Res [serial online] 2020 [cited 2020 Nov 28 ];10:226-233
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2020;volume=10;issue=4;spage=226;epage=233;aulast=Pandey;type=0