International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 10  |  Issue : 3  |  Page : 178--182

Treatment outcomes of patients receiving combination antiretroviral therapy under the national acquired immunodeficiency syndrome control programme


Vishal Malhotra1, Sanjeev Mahajan2, Virender Verma1, Apurba Patra3, Rajinder Singh Balgir1 
1 Department of Community Medicine, Government Medical College, Patiala, Punjab, India
2 Department of Community Medicine, Government Medical College, Amritsar, Punjab, India
3 Department of Anatomy, AIIMS, Bhathinda, Punjab, India

Correspondence Address:
Virender Verma
House No. 105, Mansahia Colony, Patiala - 147 001, Punjab
India

Introduction: The free antiretroviral therapy (ART) initiative of the Government of India was launched on April 1, 2004, since then it is being scaled up in a phased manner. The aim of this study was to analyze the treatment outcome of patients receiving first-line ART through the National Acquired Immunodeficiency Syndrome Control Programme of India. Materials and Methods: This was an record-based retrospective analysis of data of patients who were put on ART from January 2009 to December 2009. Results: Of the 548 patients (63.87% males; median age of 37 years), 55% of patients were employed and majority of them have low monthly income. Patients showed a significant improvement in clinical and functional status after staring ART therapy, as percentage of patients in clinical Stage 1 increased significantly (from 35.5% to 90.3%) and that of Stage 3 and 4 decreased drastically. Ninety percent of patients were working, and none was bedridden after 2 years of ART. Patients with >95% adherence to ART showed more improvement than those with <95% adherence (40% patients). The median increase in cluster of differentiation 4 (CD4) count was 134 cells/mm3 at 6 months, 185 cells/mm3 at 12 months, and 255 cells/mm3 at 24 months. Majority of patients died in clinical staging 4 with CD4 cell count <50 cells/mm3. Over 2 year's period, 20% patients died and 9.31% were lost to follow-ups (LFUs). Conclusion: Early detection, timely treatment, and long-term adherence are the keys for the success of ART programme in India; it is of utmost importance to do intense Information Education Communication/Behavioral Change Communication, regular monitoring, up-to-date record keeping, tracking of LFUs, and triangulation and data analysis for timely action and for consolidation of success made so far.


How to cite this article:
Malhotra V, Mahajan S, Verma V, Patra A, Balgir RS. Treatment outcomes of patients receiving combination antiretroviral therapy under the national acquired immunodeficiency syndrome control programme.Int J App Basic Med Res 2020;10:178-182


How to cite this URL:
Malhotra V, Mahajan S, Verma V, Patra A, Balgir RS. Treatment outcomes of patients receiving combination antiretroviral therapy under the national acquired immunodeficiency syndrome control programme. Int J App Basic Med Res [serial online] 2020 [cited 2021 Oct 25 ];10:178-182
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2020;volume=10;issue=3;spage=178;epage=182;aulast=Malhotra;type=0