International Journal of Applied and Basic Medical Research

CASE REPORT
Year
: 2018  |  Volume : 8  |  Issue : 1  |  Page : 45--47

Spironolactone-induced unilateral gynecomastia


Sahana Hadihalli Veeregowda, Jayakumar Jyothinagaram Krishnamurthy, Bhuvana Krishnaswamy, Sarala Narayana 
 Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India

Correspondence Address:
Dr. Sarala Narayana
Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar - 563 101, Karnataka
India

Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia. Within a month of stopping the drug, pain in the right breast subsided followed by decrease in size of swelling. Literature search indicates bilateral gynecomastia by spironolactone, but when clinician encounters unilateral presentation, they should consider the possibility of drug-induced etiology. Patients should be educated about this while prescribing, and eplerenone can be a safe alternative.


How to cite this article:
Veeregowda SH, Krishnamurthy JJ, Krishnaswamy B, Narayana S. Spironolactone-induced unilateral gynecomastia.Int J App Basic Med Res 2018;8:45-47


How to cite this URL:
Veeregowda SH, Krishnamurthy JJ, Krishnaswamy B, Narayana S. Spironolactone-induced unilateral gynecomastia. Int J App Basic Med Res [serial online] 2018 [cited 2020 Dec 5 ];8:45-47
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2018;volume=8;issue=1;spage=45;epage=47;aulast=Veeregowda;type=0