International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 4  |  Issue : 2  |  Page : 72--76

Does short-term exposure to elevated levels of natural gamma radiation in Ramsar cause oxidative stress?


SMJ Mortazavi1, A Niroomand-Rad2, P Roshan-Shomal4, SMT Razavi-Toosi3, M Mossayeb-Zadeh5, M Moghadam4 
1 Department of Medical Physics and Medical Engineering; Ionizing and Non-ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Emeritus Professor, Department of Radiation Medicine, Georgetown University, Washington DC, USA
3 Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Nuclear Physics, Guilan University of Science, Rasht, Gilan, Iran

Correspondence Address:
Prof. SMJ Mortazavi
Department of Medical Physics and Medical Engineering, School of Medicine, Zand, Shiraz
Iran

Background: Ramsar, a city in northern Iran, has areas with some of the highest recorded levels of natural radiation among inhabited areas measured on the earth. Aims: To determine whether short-term exposure to extremely high levels of natural radiation induce oxidative stress. Materials and Methods: In this study, 53 Wistar rats were randomly divided into five groups of 10-12 animals. Animals in the 1 st group were kept for 7 days in an outdoor area with normal background radiation while the 2 nd , 3 rd , 4 th and 5 th groups were kept in four different outdoor areas with naturally elevated levels of gamma radiation in Ramsar. A calibrated RDS-110 survey meter, mounted on a tripod approximately 1 m above the ground, was used to measure exposure rate at each location. On days 7 and 9 blood sampling was performed to assess the serum levels of catalase (CAT) and malondialdehyde (MDA). On day 8, all animals were exposed to a lethal dose of 8 Gy gamma radiations emitted by a Theratron Phoenix (Theratronics, Canada) Cobalt-60 (55 cGy/min) at Radiotherapy Department of Razi Hospital in Rasht, Iran. Results: Findings obtained in this study indicate that high levels of natural radiation cannot induce oxidative stress. CAT and MDA levels in almost all groups were not significantly different (P = 0.69 and P = 0.05, respectively). After exposure to the lethal dose, CAT and MDA levels in all groups were not significantly different (P = 0.054 and P = 0.163, respectively). Conclusions: These findings indicate that short-term exposure to extremely high levels of natural radiation (up to 196 times higher than the normal background) does not induce oxidative stress.


How to cite this article:
Mortazavi S, Niroomand-Rad A, Roshan-Shomal P, Razavi-Toosi S, Mossayeb-Zadeh M, Moghadam M. Does short-term exposure to elevated levels of natural gamma radiation in Ramsar cause oxidative stress?.Int J App Basic Med Res 2014;4:72-76


How to cite this URL:
Mortazavi S, Niroomand-Rad A, Roshan-Shomal P, Razavi-Toosi S, Mossayeb-Zadeh M, Moghadam M. Does short-term exposure to elevated levels of natural gamma radiation in Ramsar cause oxidative stress?. Int J App Basic Med Res [serial online] 2014 [cited 2021 Sep 16 ];4:72-76
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2014;volume=4;issue=2;spage=72;epage=76;aulast=Mortazavi;type=0