International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 4  |  Issue : 1  |  Page : 28--33

Antioxidant effect of isoflavones: A randomized, double-blind, placebo controlled study in oophorectomized women


Rakesh Mittal1, Niti Mittal1, Debasish Hota2, Vanita Suri3, Neelam Aggarwal3, Amitava Chakrabarti2 
1 Department of Pharmacology, Pt B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
2 Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Rakesh Mittal
Department of Pharmacology, Pt B D Sharma Postgradaute Institute of Medical Sciences, Rohtak, Haryana
India

Background: One of the postulated mechanism for cardioprotective potential of isoflavones is their ability to exert antioxidant action. However, various reports give conflicting results in this area. Aim: The present study was conducted with an objective to probe into the cardioprotective mechanism of isoflavones by evaluating their antioxidant potential in oophorectomized women. Materials and Methods: This was a randomized, double-blind, parallel, placebo controlled study. A total of 43 women were randomized to receive 75 mg/day isoflavones tablet or placebo for 12 weeks. Red blood cell antioxidant parameters including lipid peroxidation, superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) were determined at baseline and at the end of the study. Results: After 12 weeks of administration of isoflavones, there was no statistically significant difference in lipid peroxidation (P value for isoflavones: 0.37; for placebo: 0.37), catalase (P value for isoflavones: 0.35; for placebo: 0.84), SOD (P value for isoflavones: 0.41; for placebo: 0.28) and GSH-Px (P value for isoflavones: 0.92; for placebo: 0.29). There was no statistically significant difference in the proportion of patients experiencing adverse events in the two groups (P -1.00). Conclusion: The study strengthens the concept that the cardioprotective mechanism of isoflavones might be due to some other reason apart from the antioxidant pathway.


How to cite this article:
Mittal R, Mittal N, Hota D, Suri V, Aggarwal N, Chakrabarti A. Antioxidant effect of isoflavones: A randomized, double-blind, placebo controlled study in oophorectomized women.Int J App Basic Med Res 2014;4:28-33


How to cite this URL:
Mittal R, Mittal N, Hota D, Suri V, Aggarwal N, Chakrabarti A. Antioxidant effect of isoflavones: A randomized, double-blind, placebo controlled study in oophorectomized women. Int J App Basic Med Res [serial online] 2014 [cited 2021 Sep 16 ];4:28-33
Available from: https://www.ijabmr.org/article.asp?issn=2229-516X;year=2014;volume=4;issue=1;spage=28;epage=33;aulast=Mittal;type=0