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Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 18-22

The diagnostic accuracy of rapid urease biopsy test compared to histopathology in implementing "test and treat" policy for Helicobacter pylori

1 Department of Pathology, IQ City Medical College, Durgapur, West Bengal, India
2 Department of Pathology, Gauhati Medical College, Guwahati, Assam, India

Correspondence Address:
Asitava Deb Roy
Department of Pathology, IQ City Medical College, Sovapur, Bijra Road, Jaymua, Durgapur - 713 206, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-516X.174003

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Background: Helicobacter pylori is one of the most important causes of the varied spectrum of gastroduodenal diseases. It is important to have a rapid diagnostic method to detect the organism so as to initiate the treatment early and check its progression to malignancy. Aims: To evaluate the diagnostic accuracy of rapid urease biopsy test in detecting H. pylori infection and implementation of "test and treat" policy. Materials and Methods: All patients of chronic dyspepsia not responding to conventional treatment were subjected to endoscopy, and mucosal biopsy samples were collected. A rapid urease test (RUT) and histopathology was performed on these samples and taking histopathology as gold standard for H. pylori demonstration, the diagnostic accuracy of RUT was evaluated. Results: The specificity, sensitivity, positive predictive value, negative predictive value, and diagnostic accuracy of RUT were 97.22%, 94.04%, 98.75%, 87.5%, and 95%, respectively. Conclusion: Use of a rapid diagnostic test viz., rapid urease biopsy test to confirm H. pylori infection is recommended for early diagnosis and treatment of H. pylori associated gastroduodenal diseases.

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