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Year : 2015  |  Volume : 5  |  Issue : 2  |  Page : 106-110

A comparative study to evaluate the efficacy and safety of combination topical preparations in acne vulgaris

1 Department of Pharmacology, Government Medical College, Patiala, Punjab, India
2 Department of Dermatology and Venereal Diseases, Rajindra Hospital, Government Medical College, Patiala, Punjab, India

Correspondence Address:
Jasleen Kaur
Department of Pharmacology, Government Medical College, Patiala, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-516X.157155

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Background: The combinations of topical keratolytics with anti-microbials and topical retinoids with antimicrobials are commonly prescribed in the treatment of acne. Aim: The present study was undertaken with the aim of comparing the efficacy and safety of topical benzoyl peroxide and clindamycin versus topical benzoyl peroxide and nadifloxacin versus topical tretinoin and clindamycin in patients of acne vulgaris. Materials and Methods: 100 patients between 15 and 35 years having ≥2 and ≤30 inflammatory and/or noninflammatory lesions with Investigator's Global Assessment (IGA) score 2/3 were randomly divided into 3 groups. Group A was prescribed benzoyl peroxide 2.5% gel and clindamycin 1% gel, Group B was prescribed benzoyl peroxide 2.5% gel and nadifloxacin 1% cream and Group C was prescribed tretinoin 0.025% and clindamycin 1% gel. Total number of lesions and adverse effects during the treatment were assessed at 0, 4, 8, 12 weeks with IGA score. Results: There was statistically significant reduction in total number of lesions with better improvement in Group A. Adverse drug reactions during the study showed a better safety profile of Group B which is found to be statistically significant also. Conclusion: These findings confirm that Group A is more efficacious and Group B is safest among the other two groups.

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