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Year : 2013  |  Volume : 3  |  Issue : 1  |  Page : 66-68

Infantile rhabdomyofibrosarcoma: A potentially underdiagnosed aggressive tumor

1 Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India
2 Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
3 Consultant Pediatric Hematologist and Oncologist, Bombay Hospital and Medical Research Centre, Mumbai, India

Correspondence Address:
Narendra Chaudhary
Department of Child Health, Christian Medical College, Vellore - 632 004, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-516X.112244

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Infantile Rhabdomyofibrosarcoma (IRMFS) is a rare clinicopathological entity that resembles infantile fibrosarcoma (IFS) but has ultrastructural and immunohistochemical evidence of rhabdomyoblastic differentiation. We report a 2 years and 6 months old boy who presented with a slowly progressive large soft-tissue mass in left axillary region. After complete excision, histopathology report revealed diagnosis of IFS. Review of the histopathology with immunohistochemistry (positive for desmin) revealed diagnosis of IRMFS. He was treated with aggressive adjuvant chemotherapy. He was in complete remission 6 months after completion of chemotherapy. In view of poor prognosis and aggressive treatment approaches for IRMFS, it must be differentiated from IFS to avoid under treatment.

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