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Year : 2012  |  Volume : 2  |  Issue : 2  |  Page : 102-106

Arthroscopic synovial biopsy in definitive diagnosis of joint diseases: An evaluation of efficacy and precision

1 Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh, India
2 Bharati Vidyapeeth University, Pune, Maharashtra, India

Correspondence Address:
Onis Singhal
R11/10, Raj Nagar, Ghaziabad, Uttar Pradesh - 201 002
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-516X.106351

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Context: Arthritis is an important cause of morbidity, presenting as monoarticular or polyarticular lesion. Arthroscopic synovial aspiration and biopsy can help in arriving specific etiological diagnosis. Aim and Objectives: To evaluate the efficacy of arthroscopic synovial biopsy as a diagnostic aid and study the characteristics of synovial fluid in various joint diseases. Materials and Methods: Arthroscopic synovial biopsy along with synovial fluid analysis was studied in 30 of the 50 enrolled cases arthritis. The fluid was subjected to physical, biochemical, and cytological analysis. Results: Both rheumatoid ( n = 14, 28%) and tubercular ( n = 13, 26%) arthritis were found to be more common compared to other etiologies. Next common etiology observed was chronic nonspecific synovitis ( n = 10, 20%). Clinicopathological correlation was seen in 34 out of 50 cases. As a diagnostic tool, synovial biopsy had a sensitivity of 85%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 62%. Conclusion : Arthroscopic synovial biopsy is a simple and easy to perform technique and is an important useful investigative adjunct that may give conclusive diagnosis where clinical diagnosis is equivocal.

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