International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 9  |  Issue : 1  |  Page : 27--31

Protein 53, B-Cell Lymphoma-2, Cyclooxygenase-2, and CD105 reactivity in keratocystic odontogenic tumors: An immunohistochemical analysis


Ravi Nimmanagoti, S R K Nandan, Pavan G Kulkarni, Shyam Prasad Reddy, M Keerthi, Gouri Pupala 
 Department of Oral pathology & Maxillofacial, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India

Correspondence Address:
Dr. S R K Nandan
Department of Oral Pathology, Kamineni Institute of Dental Sciences, Narketpally - 508 254, Telangana
India

Objective: The objective is to evaluate and compare immunohistochemically, the biological behavior of keratocystic odontogenic tumor (KCOT) with normal oral mucosa by analyzing cell proliferation, angiogenesis, and antiapoptosis using cyclooxygenase-2 (COX-2), protein 53 (p53), B-cell lymphoma-2 (Bcl-2), and CD105 (endoglin). Materials and Methods: The present study comprised 30 cases of KCOT in the study group, in which the expression of COX-2, p53, Bcl-2, and CD105 were analyzed and compared with that of control group consisting of 30 normal oral mucosae. Results: The results were evaluated based on a number of positively stained cells; among 30 samples of KCOT, 22 samples were p53 positive, 23 samples were Bcl-2 positive, 18 samples were COX-2 positive, whereas all the above markers were negative in all the 30 samples of the normal oral mucosa and CD105 mean vascular density in KCOT 13.8 in normal oral mucosa. Conclusion: The present study suggests that angiogenesis, cell proliferation, and antiapoptosis may be the possible factors contributing for the unique biological behavior of KCOT.


How to cite this article:
Nimmanagoti R, Nandan S R, Kulkarni PG, Reddy SP, Keerthi M, Pupala G. Protein 53, B-Cell Lymphoma-2, Cyclooxygenase-2, and CD105 reactivity in keratocystic odontogenic tumors: An immunohistochemical analysis.Int J App Basic Med Res 2019;9:27-31


How to cite this URL:
Nimmanagoti R, Nandan S R, Kulkarni PG, Reddy SP, Keerthi M, Pupala G. Protein 53, B-Cell Lymphoma-2, Cyclooxygenase-2, and CD105 reactivity in keratocystic odontogenic tumors: An immunohistochemical analysis. Int J App Basic Med Res [serial online] 2019 [cited 2019 Nov 16 ];9:27-31
Available from: http://www.ijabmr.org/article.asp?issn=2229-516X;year=2019;volume=9;issue=1;spage=27;epage=31;aulast=Nimmanagoti;type=0