International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 8  |  Issue : 4  |  Page : 217--219

Human papillomavirus in urothelial carcinoma of bladder: An Indian study


Uttam K Mete1, Sunil Shenvi2, Mini P Singh3, Anuradha Chakraborti4, Nandita Kakkar5, Radha Kanta Ratho3, Arup K Mandal1 
1 Department of Urology, PGIMER, Chandigarh, India
2 Consultant, Multiorgan Transplantation & HPB Surgery, Ruby Hall Clinic, Pune, India
3 Department of Virology, PGIMER, Chandigarh, India
4 Department of Experimental Medicine, PGIMER, Chandigarh, India
5 Department of Histopathology, PGIMER, Chandigarh, India

Correspondence Address:
Dr. Sunil Shenvi
F2, Sunflower Apt, Khanapur Road, Near 3rd Gate, Tilakwadi, Belgaum - 590 006, Karnataka
India

Objectives: To study the role of high-risk human papillomavirus (HPV-16 and HPV-18) types in the causation of urothelial carcinoma of the urinary bladder in Indian population. Methods: 50 patients with Urothelial carcinoma of the urinary bladder were included in the study. Another 10 age-matched subjects who were hospitalized for transurethral resection of prostate for benign prostatic hyperplasia and/or ureterorenoscopy for ureteric stone disease were enrolled as controls. The tissue samples were analyzed for the presence of HPV-16 and HPV-18 DNA by polymerase chain reaction (PCR). The histopathology of the tumor tissue was carried out to assess the grade of the tumor. Results: The mean age of the patients was 54.1 years. A total of 28 (56%) patients had high-grade tumors and 22 (44%) had low-grade disease. T2 or higher stage disease was observed in 18 (36%) patients. All cancerous specimens and control specimens were found to be negative by PCR for the presence of HPV DNA. Conclusion: HPV prevalence in the urothelium is very low irrespective of the stage and grade of the disease, and hence, it is unlikely to be the causative agent for urothelial carcinoma of the urinary bladder in Indian population. However, the role of other HPV types in the etiology of this tumor needs to be clarified.


How to cite this article:
Mete UK, Shenvi S, Singh MP, Chakraborti A, Kakkar N, Ratho RK, Mandal AK. Human papillomavirus in urothelial carcinoma of bladder: An Indian study.Int J App Basic Med Res 2018;8:217-219


How to cite this URL:
Mete UK, Shenvi S, Singh MP, Chakraborti A, Kakkar N, Ratho RK, Mandal AK. Human papillomavirus in urothelial carcinoma of bladder: An Indian study. Int J App Basic Med Res [serial online] 2018 [cited 2019 Jun 25 ];8:217-219
Available from: http://www.ijabmr.org/article.asp?issn=2229-516X;year=2018;volume=8;issue=4;spage=217;epage=219;aulast=Mete;type=0