International Journal of Applied and Basic Medical Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 8  |  Issue : 2  |  Page : 106--110

Insulin sensitivity, inflammation, and basal metabolic rate in adults with sickle cell anemia


Kehinde Sola Akinlade1, Ayodeji Samuel Kumuyi1, Sheu Kadiri Rahamon2, John Ayodele Olaniyi3 
1 Department of Chemical Pathology, University College Hospital, University of Ibadan, Ibadan, Nigeria
2 Department of Biochemistry, College of Medical Sciences, Edo University, Iyamho, Edo State, Nigeria
3 Department of Haematology, University College Hospital, University of Ibadan, Ibadan, Nigeria

Correspondence Address:
Dr. Kehinde Sola Akinlade
Department of Chemical Pathology, Endocrinology/Metabolic Research Unit, University of Ibadan/University College Hospital, PMB 5116, Ibadan 200212
Nigeria

Background: Chronic inflammation and elevated basal metabolic rate (BMR) are established features of sickle-cell anemia (SCA). However, there is little information on the possible impacts of these afore-mentioned features on glycemia and insulin sensitivity status of this group of people. Aim: This study aims to determine the insulin sensitivity status as well the effect of BMR on glycemia in adults with SCA in steady state. Materials and Methods: Fifty participants comprising 30 adults with SCA in steady state and 20 age- and gender-matched apparently healthy adults with hemoglobin genotype AA (HbAA) genotype that served as controls. Anthropometric and clinical indices were obtained using standard methods. After an overnight fast, fasting plasma glucose (FPG), and serum insulin levels were determined using the glucose oxidase method and ELISA, respectively. Indices of insulin sensitivity and β-cell function as well as BMR were appropriately calculated. Results: The mean fasting insulin resistance (IR) index, homeostatic model of assessment of IR (HOMA-IR) and of β-cell function (HOMA2-β%), and mean insulin level were significantly lower while the mean HOMA of insulin sensitivity (HOMA2-S%), quantitative insulin sensitivity check index, inverse of insulin sensitivity (1/FI), glucose-insulin ratio, C-reactive protein (CRP), and BMR was significantly higher in patients with SCA compared with the controls. The mean FPG and insulin levels and the mean values of indices of insulin sensitivity and secretion were not significantly different in SCA patients with elevated BMR compared with SCA patients with lower BMR. In addition, BMR had no significant correlation with FPG and HOMA-IR in patients with SCA. Conclusion: Despite the established chronic inflammation in SCA patients in steady state, they seem to have better insulin sensitivity status but impaired β-cell activity when compared with adults with HbAA. Furthermore, BMR does not have any pronounced effect on glycemic and insulin sensitivity status in SCA patients in steady state.


How to cite this article:
Akinlade KS, Kumuyi AS, Rahamon SK, Olaniyi JA. Insulin sensitivity, inflammation, and basal metabolic rate in adults with sickle cell anemia.Int J App Basic Med Res 2018;8:106-110


How to cite this URL:
Akinlade KS, Kumuyi AS, Rahamon SK, Olaniyi JA. Insulin sensitivity, inflammation, and basal metabolic rate in adults with sickle cell anemia. Int J App Basic Med Res [serial online] 2018 [cited 2020 Sep 22 ];8:106-110
Available from: http://www.ijabmr.org/article.asp?issn=2229-516X;year=2018;volume=8;issue=2;spage=106;epage=110;aulast=Akinlade;type=0