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ORIGINAL ARTICLE
Year : 2020  |  Volume : 10  |  Issue : 1  |  Page : 22-24

Glycogen accumulation in neutrophil can be a marker of sepsis


1 Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
2 Department of Anaesthesiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India
3 Department of General Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Amit Ghosh
Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar - 751 019, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijabmr.IJABMR_350_18

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Background: Sepsis, a systemic inflammatory reaction to infection, is the leading cause of death in the world. The early detection and identification of pro-inflammatory changes in overall metabolism and functioning can help in the proper intervention and control of the inflammatory state, and it will improve the prognosis. Aim: In a resource-limited setting where the biomarkers are not easily accessible, this simple technique is required that can help in the early identification of infection and inflammation. Methodology: The present study was conducted to find the change in glycogen accumulation and morphological changes during inflammation by preparing a peripheral smear and periodic acid–Schiff (PAS) staining. Results: This study shows that the neutrophil accumulates glycogen granules throughout the cytoplasm with the presence of vacuoles in the cytoplasm, thus increasing the neutrophil size and chromatin dispersion. Conclusion: PAS staining can be used as a diagnostic method to detect sepsis.


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