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ORIGINAL ARTICLE
Year : 2019  |  Volume : 9  |  Issue : 4  |  Page : 206-211

A study on hepatitis B viral seromarkers and associated risk factors among the patients suffering from acute and chronic hepatitis B infection


1 Department of Microbiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
2 Department of Gastroenterology, Chettinad Super Speciality Hospital, Kelambakkam, Tamil Nadu, India
3 Department of General Medicine, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India

Correspondence Address:
Dr. S Jayanthi
Professor, Department of Microbiology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijabmr.IJABMR_263_18

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Background: Hepatitis B viral infection is the most common cause of hepatitis, and it leads to serious liver diseases such as cirrhosis and hepatocellular carcinoma. Aim: The aim of the study is to differentiate acute hepatitis B and chronic hepatitis B (CHB) among patients seropositive for hepatitis B surface antigen (HBsAg). Materials and Methods: This study was carried out in the Department of Microbiology, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, India, for a period of 6 months (January 2018–June 2018). Blood samples were collected from 87 patients for the detection of hepatitis B virus (HBV) serological markers. HBsAg, hepatitis B e antigen (HBeAg), anti-HBc total, anti-HBc IgM, and antibody to hepatitis B surface antigen were screened using the ELISA method. Detailed demographic profile including history of previous hepatitis infection, previous blood transfusion, and other related details were collected and documented using a structured questionnaire. Results: A total of 87 patients were HBsAg seropositive; among them, 55 (63.2%) were male and 32 (36.9%) were female. Based on the serological markers tested, 24 and 63 were suffering from acute and chronic HBV infections, respectively. Among the acute hepatitis B patients, all samples were seropositive for HBsAg, anti-HBc total, and anti-HBc IgM. HBeAg seromarker was found in 15 patients (62.5%). Among the CHB patients, all samples were seropositive for HBsAg and anti-HBc total. HBeAg seromarker was found in 28 patients with 44.4%. Alcohol consumption was the major risk factor for the transmission of HBV infection. Conclusion: An increased sample size and detailed study of high-risk behavior will provide an alarming awareness of their association.


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