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CASE REPORT
Year : 2018  |  Volume : 8  |  Issue : 4  |  Page : 263-265

Sepsis in a 4-month-old boy due to carbapenem-resistant Enterobacteriaceae characterized by AmpC β-lactamase with porin loss


1 Department of Emergency and Intensive Care Unit, Shiga University of Medical Science, Otsu, Shiga, Japan
2 Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan

Correspondence Address:
Dr. Junji Shimizu
Department of Emergency and Intensive Care Unit, Shiga University of Medical Science, Seta Tsukinowa-Cho, Otsu, Shiga, 520-2192
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijabmr.IJABMR_383_17

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The incidence of carbapenem-resistant Enterobacteriaceae (CRE) infections is increasing, and these infections are associated with both morbidity and mortality. However, little is known about CRE infections in children. This article is a case report describing a 4-month-old boy with Langerhans histiocytosis who developed septic shock due to a CRE infection. The mechanism of carbapenem resistance was identified as AmpC β-lactamase hyperproduction with porin loss. The patient was treated with antibiotics, volume resuscitation, and vasopressors; however, he died of multiorgan failure due to CRE infection. Clinicians should be aware of the prevalence of CRE and the importance of prevention strategies against infection with multidrug-resistant bacteria, even in pediatric populations.


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