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CASE REPORT
Year : 2018  |  Volume : 8  |  Issue : 1  |  Page : 57-60

Primary hemochromatosis presenting as Type 2 diabetes mellitus: A case report with review of literature


1 Department of Pathology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India
2 Department of Pathology, ESIC Medical College & PGIMSR and Model Hospital, Bangalore, Karnataka, India

Correspondence Address:
Prof. Kalyani Raju
H.No: 127/13, “Sri Ganesh”, 4th Main, 4th Cross, PC Extension, Kolar - 563 102, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijabmr.IJABMR_402_16

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Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance. Early diagnosis and treatment of hemochromatosis prevents the development of diabetes. We present a case in a 48-year-old male with a history of DM for 6 months and skin pigmentation over face for 1 year.


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