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ORIGINAL ARTICLE
Year : 2016  |  Volume : 6  |  Issue : 4  |  Page : 267-270

Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia


1 Department of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan
2 Department of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan
3 Department of Histopatology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan
4 Laboratory Diagnostic and Councelation Centre, Khartoum, Sudan

Correspondence Address:
Dr. Elshazali Widaa Ali
Department of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum
Sudan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-516X.192594

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Context: Sickle cell anemia (SCA) is a group of hemoglobin disorders in which the sickle β-globin gene is inherited. It is associated with many complications; most of them are related to thrombotic events. Aim: This study aimed to investigate the association between angiotensin converting enzyme (ACE) insertion/deletion polymorphism and complications of SCA. Settings and Design: A case–control study was conducted in Khartoum state. Subjects and Methods: A total of 50 patients with SCA and 40 healthy volunteers as a control group were enrolled in this study. Three milliliters of ethylenediamine tetraacetic acid anticoagulated blood were collected from each subject, DNA was extracted by salting-out method, and target DNA regions of the ACE gene were amplified using allele-specific polymerase chain reaction. Statistical Analysis Used: Data of this study was analyzed by Statistical Package for Social Sciences. Frequency of qualitative variables was calculated, and correlation was tested by Chi-square test. Regression was used to investigate the association between the polymorphism and complications of SCA. Results: The frequencies of the DD, ID, and II genotypes were 42%, 50%, and 8%, respectively, for patients, whereas in the control group, it was 80% for DD genotype and 20% for ID, while II genotype was totally absent. The regression analysis showed no statistically significant association between the disease complications and each of the ACE polymorphic genotypes. Conclusion: No statistically significant association was found between ACE polymorphism and complications of SCA.


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