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LETTER TO THE EDITOR
Year : 2013  |  Volume : 3  |  Issue : 2  |  Page : 134  

Nature identical curcumin


Laurus Labs Private Limited, Hyderabad, Andhra Pradesh, India

Date of Web Publication27-Aug-2013

Correspondence Address:
Roopesh Jain
2nd Floor, Serene Chamber, Road No. 7, Banjara Hills, Hyderabad 500 034, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-516X.117104

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How to cite this article:
Jain R. Nature identical curcumin. Int J App Basic Med Res 2013;3:134

How to cite this URL:
Jain R. Nature identical curcumin. Int J App Basic Med Res [serial online] 2013 [cited 2020 Jan 19];3:134. Available from: http://www.ijabmr.org/text.asp?2013/3/2/134/117104

Sir,

Curcumin is a bright yellow to orange color compound present in turmeric and has been known for its health promoting, coloring and cosmetic properties since ancient times. [1] This molecule has been the object of several pharmacological investigations over the last few decades and identified as a single agent which can regulate multiple targets such as transcription factors, cytokines, protein kinases, inflammatory enzymes and adhesion molecules etc., making it effective against many targeted illness. [2] Various studies suggest that curcumin has potential as an antiproliferative and antiangiogenic agent; as a mediator of chemoresistance and radioresistance; as a anti-oxidant; and as a therapeutic agent in wound healing, diabetes, Alzheimer disease, cardiovascular disease, pulmonary disease, and arthritis etc. [3]

Curcumin is the principal component (about 77%) in the natural turmeric extract along with Demethoxycurcumin (about 17%), Bisdemethoxycurcumin (about 3%). Curcumin is reported to possess high free radical scavenging activity compared to other Curcuminoids and attributed to its methoxy groups. [4] Laurus has developed a novel process for Curcumin identical to natural Curcumim with a high purity upto 99%. Laurus offers Nature Identical (NI) Curcumin with consistent quality and our product avoids inherent problems associated with extraction of Curcumin from natural source (turmeric), e.g., variation in potency of extract due to variation in natural plant materials, co-occurring impurities etc.

The efficacy of Nature Identical (NI) Curcumin manufactured by Laurus has been validated for anti-oxidant (total ORAC), anti-inflammatory (TNF-α induced NF-κB) activities and through comparative pharmacokinetics.

Anti-oxidant activity: The ORAC (Oxygen Radical Absorbance Capacity) of NI Curcumin was studied at Brunswick Laboratory against five predominant reactive species found in the body: Peroxyl radicals, hydroxyl radicals, peroxynitrite, super oxide anion and singlet oxygen; and identified that NI Curcumin has exhibited high anti-oxidant activity with total ORAC value, over 1500000 μmole TE/g.

Anti-inflammatory activity: The anti-inflammatory activity of NI Curcumin was studied in Human 293 T Cells. The level of NF-κB was 49.33 μmol QE/g of Quercetin activity when tested at 1mg/ml Curcumin. This indicates that Nature Identical Curcumin down-regulates TNF-α induced NF-Kappa B expression. No toxic signs were observed with the compound at 1 mg/ml against Human 293 T cells and found safe.

Pharmacokinetics: In a study conducted at a NABL (National Accreditation Board for Testing and Calibration Laboratories) certified and US FDA audited testing laboratory; the NI Curcumin has shown the same pharmacokinetic profile as natural Curcumin in female Wistar rats.

Global warming and climate change are the foremost environmental challenges facing the world today and it is the responsibility of all to minimise the emission of greenhouse gases (GHG) from human activities. [5] The emission of GHG from a manufacturing process can be measured by Carbon Footprint analysis. Applying the same for manufacturing of NI Curcumin indicated that the Carbon Footprint for the NI Curcumin produced by synthesis is lower than that of manufacturing of natural Curcuminoids from its natural source.

The above outcome observed for NI Curcumin will surely encourage the development of synthetic methods for manufacturing of other Nature Identical compounds for human health and wellness. These methods offer alternative ways of producing valuable compounds without disturbing natural sources and preventing their exploitation beyond extinction.

 
   References Top

1.Kapoor VP. Herbal cosmetic for skin and hair care. Nat Prod Rad 2005;4:306-14.  Back to cited text no. 1
    
2.Shehzad A, Lee YS. Molecular mechanisms of curcumin action: Signal transduction. Biofactors 2013;39:27-36.  Back to cited text no. 2
[PUBMED]    
3.Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: From farm to pharmacy. Biofactors 2013;39:2-13.  Back to cited text no. 3
[PUBMED]    
4.Sreejayan N, Rao MN. Free radical scavenging activity of curcuminoids. Arzneimittelforschung 1996;46:169-71  Back to cited text no. 4
    
5.Steinacher M, Joos F, Stocker TF. Allowable carbon emissions lowered by multiple climate targets. Nature 2013;499:197-201  Back to cited text no. 5
    



This article has been cited by
1 Synthetic curcumin: A biological monograph
Roopesh Jain,Archana Tiwari
Journal of Current Research in Scientific Medicine. 2019; 5(2): 132
[Pubmed] | [DOI]



 

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