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ORIGINAL ARTICLE
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 75-79

Smoking-induced satellite associations in a rural population of south India: An in vitro study


1 Department of Anatomy, Mahatma Gandhi Medical College and Research Institute, Pillayarkuppam, Pondicherry, India
2 Respiratory Medicine, Indira Gandhi Medical College and Research Institute, Kadirkamam, Pondicherry, India

Correspondence Address:
A N Uma
Genetics Division, Anatomy Department, Mahatma Gandhi Medical College and Research Institute, Pillayarkuppam, Puducherry - 607 402
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-516X.91148

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Background: Genotoxic carcinogens in cigarette smoke interact with DNA, causing cytotoxicity. Cytogenetic damage therefore seems to be an excellent biomarker for determining the effect of exposure to chromosome-damaging agents in cigarette smoke. Purpose: To study the utility of measurement of frequency of satellite associations (SA) as a biomarker for chromosomal damage using cytogenetic assay in peripheral blood lymphocytes. Materials and Methods: This study was conducted on 30 smokers and 30 nonsmokers drawn from a rural population of South India. Smokers were divided into three groups of ten each based on their smoking index (SI) (group I: SI < 150, group II: SI 150-300, and group III: SI > 300) and the frequency of SAs was studied. Results: The frequency of SAs was significantly greater in smokers than in nonsmokers and the frequency of SAs among the smokers was also seen to increase with increase in SI. Conclusion: The results of this study indicate that the genotoxic effect of cigarette smoke on chromosomes increases with smoking intensity. These findings can be used to support smoking cessation interventions.


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